WebApr 6, 2024 · Download Citation CHCHD2 and CHCHD10-related neurodegeneration: molecular pathogenesis and the path to precision therapy In the last decade, dominant mutations in the mitochondrial protein ... WebJan 10, 2024 · Frontotemporal degeneration (FTD) is a group of disorders caused by the degeneration of the frontal and/or temporal lobes of the brain, bringing progressive changes to behavior, personality, language, and/or movement. The FTD disorders occur when specific proteins accumulate and clump together in a person’s neurons.
Mitochondrial CHCHD-Containing Proteins: Physiologic Functions …
WebJan 13, 2024 · CHCHD10 immunohistochemistry for the 3 controls and the 5 sporadic ALS cases showed strong neuronal cytoplasmic and axonal labeling, with the CHCHD10 … WebJun 8, 2024 · TDP43 protein aggregation is a key element in amyotrophic lateral sclerosis (ALS) as it has a major impact on motor neuron degeneration. ... For two other genes (CHCHD10 and CCNF) TDP43 pathology ... most affordable office chair
Loss of function CHCHD10 mutations in cytoplasmic …
WebJun 24, 2024 · The results establish that CHCHD10 mutations influence toxicity of TDP43 in neurons, however, the researchers have yet to test this in motor neurons or cortical neurons, the cell types affected in ALS or FTD. While the work connects CHCHD10 to TDP-43, many questions remain. WebSep 9, 2024 · Conversely, hyperfusion of mitochondria in fibroblasts derived from an ALS patient with CHCHD10 R15L has been reported (Straub et al., 2024). CHCHD10 variants have been reported in patients with FTD, ALS, motor neuron disease, spinal motor neuronopathy, Charcot-Marie-Tooth disease type 2, and mitochondrial myopathy. Table … WebLecturer in the biomedical research program at Avans University of Applied Sciences. Scientist with a longstanding interest in life sciences, especially (but not limited to) all things concerning molecular biology (e.g. genomics, gene expression regulation, disease mechanisms and signal transduction).In my various positions I applied my knowledge … most affordable online college programs