Hofh international consortium
Nettet16. apr. 2024 · Results: Almost 300 patients have been enrolled thus far; this analysis is based on the first 220 patients from over 17 countries.Mean±SD age at clinical diagnosis was 17.7±17.4 (Range: 1-79) years Nettet4. mar. 2024 · HICC (Homozygous FH International Clinical Collaborators) is a global consortium of clinicians who are contributing de-identified data of patients diagnosed with HoFH with the goal to advance our understanding of this rare disease. Full Title of Study: “HoFH, the International Clinical Collaborators – A Global HoFH Data-sharing Platform”
Hofh international consortium
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NettetPurpose of review: Homozygous familial hypercholesterolemia (HoFH) is a rare disorder associated with early atherosclerotic disease due to impairment of the LDL receptor (LDLR) pathway. Because of their molecular defect, current treatment options have limited success in bringing HoFH patient to LDL-C target and morbidity and mortality remain high. NettetHoFH is the rare and the most severe form of Familial Hypercholesterolemia (FH). Untreated, HoFH often causes heart disease (heart attacks and aortic valve disease) beginning in the early childhood. REMEMBER: while FH is common and impacts 1 person in 250, HoFH is a rare* disorder. It is estimated to affect as many as 1 in 300,000 …
Nettet7. apr. 2024 · Introduction Homozygous familial hypercholesterolemia (HoFH) is a rare, genetic condition in which mutations in key peptides involved in the low-density lipoprotein receptor (LDL-R) pathway result in markedly elevated levels of circulating LDL-cholesterol (LDL-C). Patients are at high risk of developing early-onset atherosclerotic … NettetAnonymized data on demographics, type of HoFH diagnosis (clinical and/or based on the results of a genetic test), genetic results, (cardiovascular) medical history, relevant family history, physical examination, laboratory measurements, lipid lowering treatment and cardiovascular imaging are collected for 3 different time points: at diagnosis, at …
Nettet24. mar. 2024 · HICC (Homozygous FH International Clinical Collaborators) is a global consortium of clinicians who are contributing de-identified data of patients diagnosed … NettetPurpose of review: Homozygous familial hypercholesterolemia (HoFH) is a rare disorder associated with early atherosclerotic disease due to impairment of the LDL receptor …
Nettet1. feb. 2024 · The authors also suggest the benefits of an international registry for HoFH and LT. The International Registry on Lipoprotein Apheresis in Children with HoFH could serve as an example (Luirink et ...
Nettet18. feb. 2024 · Patients with HoFH in the small (n = 4) ORION-2 (Sustained LDL Reduction With Inclisiran in Homozygous FH) pilot study experienced changes in LDL-C ranging … hipaa minor recordshome repair grant for hurricane damageNettetAnonymized data on demographics, type of HoFH diagnosis (clinical and/or based on the results of a genetic test), genetic results, (cardiovascular) medical history, relevant … hipaa minimum necessary standard defNettet26. des. 2024 · Consortium: A consortium is a group made up of two or more individuals, companies or governments that work together toward achieving a chosen objective. Each entity within the consortium is only ... hipaa minor birth controlNettetHomozygous Familial Hypercholesterolemia (HoFH). The most serious and more rare form is HoFH. Individuals with HoFH typically have untreated LDL levels between 400 and 1000 mg/dL. That’s four to 10 times the normal level. If left untreated, people with HoFH can develop heart disease in their early teenage years, sometimes as early as two or ... hipaa minors std rightsNettet5. okt. 2024 · Purpose of review: We reviewed current and future therapeutic options for patients with homozygous familial hypercholesterolemia (HoFH) and place this evidence in context of an adaptable treatment ... hipaa minors parentsNettet19. feb. 2024 · The HoFH International Clinical Collaborators registry collected data on patients with a clinical, or genetic, or both, diagnosis of HoFH using a retrospective … hipaa minor confidentiality