Webb5 juli 2011 · RelA binds to the PLK1 promoter and regulates PLK1 transcription, which consequently stabilizes the β-catenin protein by disrupting its interaction with GSK-3β and β-TrCP. Altogether, our study reveals critical mechanisms involved in the dysregulation of PLK1 in human tumors and the role of PLK1 in anoikis resistance. Webb23 sep. 2024 · Thus, PLK1 inhibition appears to be a promising therapeutic strategy 5, 22, although the mechanism of PLK1 upregulation by LHBs remains unclear. Finally, validating the clinical significance of their experimental results, the authors show an association between LHBs expression and hepatocyte aneuploidy in liver sections of patients with …
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Webb7 feb. 2024 · Polo-Like Kinase 1 (Plk1) expression is inversely correlated with survival advantages in many cancers. However, molecular mechanisms that underlie Plk1 expression are poorly understood. Here, we uncover a novel hypoxia-regulated mechanism of Plk1-mediated cancer metastasis and drug resistance. We demonstrated that a new … Webb4 apr. 2024 · Abstract. Targeted therapies are limited for head and neck squamous cell carcinoma (HNSCC), as it is driven by mutations in tumor suppressors, including NOTCH1. We previously identified loss of function NOTCH1 mutations in HNSCC to be sensitive to phosphoinositide-3 kinase (PI3K) inhibitors through sustained Aurora kinase B levels. … pork chop recipes with jam
Plk1, upregulated by HIF-2, mediates metastasis and drug …
Webb1 dec. 2024 · Several PLK1 mutations have been already described in resistant cells to PLK1 inhibitors. These data supported our research in this regard, and evidenced the … WebbGenetic and pharmacological blockade of PLK1 significantly increases the sensitivity to oxaliplatin in vitro and in vivo. Mechanistically, transcriptomic profiling analysis reveals … Webb5 feb. 2024 · 1 1 A novel mechanism of H IF 2-dependent P L K 1-mediated metastasis and drug resistance of 2 clear cell Renal Cell Carcinoma 3 4 5 Maeva Dufies 1*, Annelies Verbiest 2,3, Lindsay S Cooley 4, Papa Diogop Ndiaye 5, Julien Viotti 6, 6 Xingkang He 7, Nicolas Nottet 8, Wilfried Souleyreau 4, Anais Hagege 5, Stephanie Torrino 9, Julien pork chop recipes with mayonnaise